This page was initially dedicated to the scientific news concerning Covid-19 structural data. Targeted audience : graduate/doctoral schools (Universities and ReNaFoBiS)

This has been extended to other data or publications. This is not meant to be exhaustive.

 News from the structural biology centers :

General News :

Corana virus data science links :

Corona virus data :

Help needed. Your contribution is welcome

Drugs

MOOCs

Veille de la littérature médicale et scientifique dédiée au Coronavirus.

 

A short selection of articles :

  • Soper, G.A. (1919). The Lessons of the Pandemic. Science 49, 501-506.
  • Zhong, N.S., et al. (2003). Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February 2003, Lancet 362, 1353-1358.
  • Chen J, Subbarao K. The Immunobiology of SARS. Annu Rev Immunol. 2007;25:443-72
  • Hilgenfeld, R., and Peiris, M. (2013). From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses. Antiviral Res 100, 286-295.
  • Hilgenfeld, R. (2014). From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design. FEBS J 281, 4085-4096.
  • Fehr, A.R., and Perlman, S. (2015). Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol 1282, 1-23.
  • Raoult 2016, New Diagnostic Techniques Highlight the Need for Negative Controls
  • Taubenberger JK, Kash JC, Morens DM. The 1918 influenza pandemic: 100 years of questions answered and unanswered. Sci Transl Med. 2019 Jul 24;11(502).

 

  • Dongwan Kim, Joo-Yeon Lee, Jeong-Sun Yang, Jun Won Kim, V. Narry Kim, Hyeshik Chang,The Architecture of SARS-CoV-2 Transcriptome,Cell, 2020, https://doi.org/10.1016/j.cell.2020.04.011
  • MA Shereen, S Khan, A Kazmi, N Bashir, R Siddique,COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses,Journal of Advanced Research,Volume 24,2020,Pages 91-98,
  • Remuzzi, A., and Remuzzi, G. (2020). COVID-19 and Italy: what next? Lancet.
  • Yuen, K.S., Ye, Z.W., Fung, S.Y., Chan, C.P., and Jin, D.Y. (2020). SARS-CoV-2 and COVID-19: The most important research questions. Cell Biosci 10, 40.
  • Song, Z., Xu, Y., Bao, L., Zhang, L., Yu, P., Qu, Y., Zhu, H., Zhao, W., Han, Y., and Qin, C. (2019). From SARS to MERS, Thrusting Coronaviruses into the Spotlight. Viruses 11.
  • Guo, Y.R., Cao, Q.D., Hong, Z.S., Tan, Y.Y., Chen, S.D., Jin, H.J., Tan, K.S., Wang, D.Y., and Yan, Y. (2020). The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res 7, 11
  • Baig, A.M., Khaleeq, A., Ali, U., and Syeda, H. (2020). Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chem Neurosci.
  • Li, Y.C., Bai, W.Z., and Hashikawa, T. (2020). The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol.
  • Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., et al. (2020). Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA.
  • Wu, F., Zhao, S., Yu, B., Chen, Y.M., Wang, W., Song, Z.G., Hu, Y., Tao, Z.W., Tian, J.H., Pei, Y.Y., et al. (2020). A new coronavirus associated with human respiratory disease in China. Nature 579, 265-269.
  • Habibzadeh, P., and Stoneman, E.K. (2020). The Novel Coronavirus: A Bird's Eye View. Int J Occup Environ Med 11, 65-71.
  • van der Werf, S., Peltékian, C. Facing challenges with the novel coronavirus SARS-CoV-2 outbreak. Émergence du coronavirus SARS-CoV-2 : faire face à l’épidémie de Covid-19. Virologie 2020, 24 (S1) : S3-S6

 

  • Yuan, Y., Cao, D., Zhang, Y., Ma, J., Qi, J., Wang, Q., Lu, G., Wu, Y., Yan, J., Shi, Y., et al. (2017). Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains. Nat Commun 8, 15092.
  • Song, W., Gui, M., Wang, X., and Xiang, Y. (2018). Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2. PLoS Pathog 14, e1007236.
  • Gao, Y., Yan, L., Huang, Y., Liu, F., Zhao, Y., Cao, L., Wang, T., Sun, Q., Ming, Z., Zhang, L., et al. (2020). Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target. bioRxiv.
  • Jin, Z., Du, X., Xu, Y., Deng, Y., Liu, M., Zhao, Y., Zhang, B., Li, X., Zhang, L., Peng, C., et al. (2020). Structure of Mpro from COVID-19 virus and discovery of its inhibitors. bioRxiv.
  • Lan, J., Ge, J., Yu, J., Shan, S., Zhou, H., Fan, S., Zhang, Q., Shi, X., Wang, Q., Zhang, L., et al. (2020). Crystal structure of the 2019-nCoV spike receptor-binding domain bound with the ACE2 receptor. bioRxiv.
  • Tan, Y., Schneider, T., Leong, M., Aravind, L., and Zhang, D. (2020). Novel Immunoglobulin Domain Proteins Provide Insights into Evolution and Pathogenesis Mechanisms of SARS-Related Coronaviruses. bioRxiv.
  • Wrapp, D., Wang, N., Corbett, K.S., Goldsmith, J.A., Hsieh, C.-L., Abiona, O., Graham, B.S., and McLellan, J.S. (2020). Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 367, 1260-1263.
  • Yan, R., Zhang, Y., Guo, Y., Xia, L., and Zhou, Q. (2020). Structural basis for the recognition of the 2019-nCoV by human ACE2. bioRxiv.
  • Yan, R., Zhang, Y., Li, Y., Xia, L., Guo, Y., and Zhou, Q. (2020). Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2. Science.
  • Walls, A.C., Park, Y.J., Tortorici, M.A., Wall, A., McGuire, A.T., and Veesler, D. (2020). Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell.
  • Gordon, D.E. et al. (2020). A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv.
  • Zhang, L., Lin, D., Sun, X., Curth, U., Drosten, C., Sauerhering, L., Becker, S., Rox, K., and Hilgenfeld, R. (2020). Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors. Science.20 Mar 2020:eabb3405 DOI: 10.1126/science.abb3405
  • Shang J, Wan Y, Liu C, Yount B, Gully K, Yang Y, Auerbach A, Peng G, Baric R,Li F. Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry. PLoS Pathog. 2020 Mar 9;16(3)
  • Yuan M, Wu NC, Zhu X, Lee CD, So RTY, Lv H, Mok CKP, Wilson IA. A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV. Science. 2020 Apr 3. pii: eabb7269. doi: 10.1126/science.abb7269.

 

  • Ghosh AK, Brindisi M, Shahabi D, Chapman ME, Mesecar AD. Drug Development and Medicinal Chemistry Efforts Toward SARS-Coronavirus and Covid-19 Therapeutics.ChemMedChem. 2020 Apr 23. :doi: 10.1002/cmdc.202000223.
  • Jin, Z., Du, X., Xu, Y., Deng, Y., Liu, M., Zhao, Y., Zhang, B., Li, X., Zhang, L., Duan, Y., et al. (2020). Structure-based drug design, virtual screening and high-throughput screening rapidly identify antiviral leads targeting COVID-19. bioRxiv.
  • Gautret, P., Lagier, J.-C., Parola, P., Hoang, V.T., Meddeb, L., Mailhe, M., Doudier, B., Courjon, J., Giordanengo, V., Vieira, V.E., et al. (2020). Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. International Journal of Antimicrobial Agents, 105949.
  • Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Shi, Z., Hu, Z., Zhong, W., and Xiao, G. (2020). Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 30, 269-271.
  • Zhang, L., Lin, D., Kusov, Y., Nian, Y., Ma, Q., Wang, J., von Brunn, A., Leyssen, P., Lanko, K., Neyts, J., et al. (2020). alpha-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment. J Med Chem.
  • Zhang C, Huang S, Zheng F, Dai Y. Controversial treatments: an updated understanding of the Coronavirus Disease 2019. J Med Virol. 2020 Mar 26.
  • Baker EN. Visualizing an unseen enemy; mobilizing structural biology to counter COVID-19. Acta Crystallogr D Struct Biol. 2020 Apr 1;76(Pt 4):311-312
  • Sheahan TP et al.An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med. 2020 Apr 6. pii: eabb5883. doi: 10.1126/scitranslmed.abb5883.

 

Publications. Links to pdfs. (Code FirstAuthorYear)

 

More science :

 

Integrated Structural Biology. Methods and Techniques 101.

 

On line Courses/Workshops

Access to teaching documents Master BSIB UNISTRA

  • Code send on request  to  jean"(point)"cavarelli"(at)"unistra"(point)"fr. Modules et Programme 2019-2020